Current Research Trials


ARIZONA CArdiovascular research CENTER


REducing Lung Congestion Symptoms Using the V-Wave Shunt in AdVancEd Heart Failure (RELIEVE HF) Start of enrollment: 2020-01

A Study to Evaluate the Corvia Medical, Inc IASD System II to REDUCE Elevated Left Atrial Pressure in Patients With Heart Failure With Reduced Ejection Fraction (CORVIA HFrEF) Start of enrollment: 2020-10

WATCHMAN FLX versus NOAC for EMbolic ProtectION in the Management of Patients with Non-Valvular Atrial Fibrillation (CHAMPION AF) Start of enrollment: 2020-11

Supporting Patients Undergoing HIgh-Risk PCI Using a High-Flow PErcutaneous Left Ventricular Support Device (SHIELD II) Start of enrollment: 2020-10

Percutaneous MitraClip Device or Surgical Mitral Valve REpair in PAtients With PrImaRy Mitral Regurgitation Who Are Candidates for Surgery (REPAIR MR) Start of enrollment: 2020-11

Clinical Trial of Atrial Fibrillation Patients Comparing Left Atrial Appendage Occlusion Therapy to Non-Vitamin K Antagonist Oral Anticoagulants (CATALYST) Start of enrollment: 2020-10

Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure (ARISE HF) Start of enrollment: 2020-01

Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation (OPTION FLX) Start of enrollment: 2020-01-15

SyncAV Post-Market Trial (SYNC AV) Start of enrollment: 2019-11

RESTORE EF Start of enrollment: 2019-10

Clinical Trial to Evaluate Cardiovascular Outcomes In Patients Treated with Tricuspid Valve Repair System Pivotal (TRILUMINATE) Start of enrollment: 2019-09

Radial Access for Navigation to Your Chosen Lesion for Peripheral Vascular Intervention (REACH PVI) Start of enrollment: 2019-06-18

Hemodynamic-GUIDEd Management of Heart Failure (GUIDE-HF) Start of enrollment: 2019-03-19

Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of PSVT. (NODE 302) Start of enrollment: 2018-12

Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction (PERSPECTIVE) Start of enrollment: 2018-11-01

Investigational Device Evaluation of the WATCHMAN FLX™ LAA Closure Technology (PINNACLE FLX) Start of enrollment: 2018-10-15 

REDUCE LAP-HF TRIAL II (REDUCELAPHF II) Start of enrollment: 2018-10-09 

ANTHEM-HFrEF Pivotal Study Start of enrollment: 2018-06-01

Efficacy and Safety of Etripamil for the Termination of Spontaneous PSVT. NODE-301 Start of enrollment: 2018-02-02

A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF) (CAPACITY-HFpEF) Start of enrollment: 2018-02-01

Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO) Start of enrollment: 2017-09-01

AMPLATZER™ Amulet™ LAA Occluder Trial Start of enrollment: 2017-02-01

aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation Start of enrollment: 2016-12-01

Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation With Focal Impulse and Rotor Modulation Guided Procedures  Start of enrollment: 2016-11-01

MultiPoint Pacing™ Post Market Study (MPP PMS) Start of enrollment: 2016-08-01

CardioMEMS™ HF System Post Approval Study Start of enrollment: 2016-06-01

Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm  Start of enrollment: 2016-05-01

Use of a Novel Pocket Compression Device for the Prevention and Treatment of Pocket Hematoma after Pacemaker and Defibrillator Implantation (STOP-HEMATOMA)  Start of enrollment: 2016-04-01

PARACHUTE V PercutAneous Ventricular RestorAtion in Chronic Heart FailUre Due to Ischemic HearT DiseasE  Start of enrollment: 2016-04-01

St Jude Medical LV Lead – Quartet 1457Q IDE Start of enrollment: 2016-03-01

Barostim neo® – Baroreflex Activation Therapy® for Heart Failure Start of enrollment: 2015-09-01


Randomized Evaluation of Atrial Fibrillation Treatment with Focal Impulse and Rotor Modulation Guided Procedures (REAFFIRM) Start of enrollment: 2015-04-01

Quadripolar CRT-D On Currently Approved Lead SystemS CROSS X4 Study Start of enrollment: 2014-10-01

Accent MRI Pacemaker and Tendril MRI Lead New Technology Assessment Start of enrollment: 2014-01-01

Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation  Start of enrollment: 2013-10-01

Focal Impulse and Rotor Modulation Ablation Trial for Treatment of Paroxysmal Atrial Fibrillation (FIRMAT-PAF) Start of enrollment: 2013-09-01

nMARQ™ Pulmonary Vein Isolation System for the Treatment of Paroxysmal Atrial Fibrillation Start of enrollment: 2013-03-01
Tom McElderry, MD, Anil Bhandari, MD, Rob Patrawala, MD, George Monir, MD, Andrew Wickliffe, MD, David Wilber, MD, Dhanunjaya Lakkireddy, MD, Gery Tomassoni, MD, Ronald Berger…

CVRx Barostim Hypertension Pivotal Trial Start of enrollment: 2013-01-01
Vijay Swarup, Karen Woo, Gregory Trachiotis, Harischandra Karunaratne, Fadi Matar, Richard Abben, Harry Colfer, Naveed Akhtar, Chowdhury Ahsan, Branislov Schifferdecker, Srini…

Clinical Trial of the SonRtip Lead and Automatic AV-VV Optimization Algorithm in the PARADYM RF SonR CRT-D Start of enrollment: 2012-01-01
Eli GANG, Dr., Brian CHESNIE, Dr., Ishu RAO, Dr., Charan KANTIPUDI, Dr., Carmine ODDIS, Dr., Freddy ABI-SAMRA, Dr., Kevin HEIST, Dr., Parag PATEL, Dr., Mark MITCHELL, Dr., San…

Barostim HOPE4HF (Hope for Heart Failure) Study Start of enrollment: 2012-11-01
Charles Jost, Vijay Swarup, Vincent Rowe, Norman Erenrich, Harischandra Karunaratne, Fadi Matar, Nirav Raval, Richard Abben, MD, Lana Tsao, Harry Colfer, Richard Shehane, Robe…

CARTO® 3 System and Real Time Intracardiac Ultrasound Start of enrollment: 2012-10-01
Vijendra Swarup, MD, Kishlay Anand, MD, Ivan Ho, Brett Gidney, Christopher Cole, MD, Robert Fishel, MD, Farhat Khairallah, MD, Ahmad Jones, MD, Shahid Baig, MD, Gopi Dandamudi…

Continued Access to PREVAIL (CAP2) Start of enrollment: 2012-09-01
Swarup, M.D., Gery Tomassoni, M.D., and Dukkipati, M.D.

NAVISTAR® THERMOCOOL® SF Catheter: Observational Study Start of enrollment: 2012-04-01
Ali Hamzei, MD, Robert Fishel, MD, Saumit Oza, MD, Bengt Herweg, MD, Michael Chisner, MD, Joshua Moss, MD, Mohammad Khan, MD, Ziad Issa, MD, Sree Karanam, MD, Alexander Mazur,…

Safety and Efficacy of the Accent Magnetic Resonance Imaging™ (MRI) Pacemaker and Tendril MRI™ Lead Start of enrollment: 2012-03-01

Quadripolar Pacing Post Approval Study Start of enrollment: 2012-02-01
Ibrahim Hanna, MD, Scott Allison, MD, Thomas Wool, MD, Vijendra Swarup, MD, Joel Carver, MD, Scott Beau, MD, Viral Mehta, MD, Thomas Ahern, MD, Philip Chang, MD, Bing Liem, MD…

ST Monitoring to Detect Acute Coronary Syndrome Events in Implantable Cardioverter Defibrillator Patients Start of enrollment: 2011-08-01
Hugh Thomas McElderry, MD, Sanjeev Hasabnis, DO, Scott Allison, MD, Scott Beau, MD, Mark Starling, MD, Vijendra Swarup, MD, Stephen Greer, MD, Peter Nalos, MD, Sue Eisenberg, …

Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover Start of enrollment: 2010-11-01

Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy Start of enrollment: 2010-11-01

QuickFlex Micro Post Approval Study Start of enrollment: 2010-08-01

Multicenter Automatic Defibrillator Implantation Trial – Reduce Inappropriate Therapy Start of enrollment: 2009-09-01

NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Drug Refractory Recurrent Symptomatic Paroxysmal Atrial Fibrillation Start of enrollment: 2009-09-01
Anthony Magnano, MD, Saumil Oza, MD, David Wilber, MD, Gery Tomassoni, MD, Hugh Calkins, MD, Timm Dickfeld, MD, Pirooz Mofrad, MD, Charles Haffajee, MD, Roy John, MD, Jay Simo…

Condition of Approval Study: Longitudinal Surveillance Registry of the ACUITY Spiral Lead Start of enrollment: 2009-08-01
Alawwa, A.,Angella, F.,Atiga, W.,Bailey, M.,Bedi, M.,Belott, P.,Bonometti, C.,Chan, R.,Compton, S.,DeBruyn, V.,Desai, P.,Dizon, J.,Doppalapudi, H.,Doshi, R.,Esberg, D.,Feldman…

Detect Fluid Early From Intra-thoracic Impedance Monitoring Start of enrollment: 2009-05-01

Model 4195 Left Ventricular (LV) Lead Chronic Performance StudyStart of enrollment: 2009-03-01

Post Approval Registry of Corox OTW, Endocardial, Left Ventricular Steroid Lead, Bipolar Start of enrollment: 2008-12-01

Long-term Evaluation of the Linox Family ICD Leads Registry (GALAXY) Start of enrollment: 2008-12-01

Safety and Efficacy Study of the QuickFlex Micro Model 1258T Left Heart Pacing Lead Start of enrollment: 2008-10-01

Study of New Implantable Loop Recorder Start of enrollment: 2008-09-01

Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke RiskStart of enrollment: 2008-02-01

St. Jude Medical Product Longevity and Performance (SCORE) Registry Start of enrollment: 2007-11-01

Tailored Treatment of Permanent Atrial Fibrillation Start of enrollment: 2007-05-01

Pivotal Clinical Study of Endoscopic Ablation for Atrial Fibrillation (AF) in Patients That Have Failed Drugs Start of enrollment: 2007-03-01

Attain Model 4196 Left Ventricular (LV) Lead Start of enrollment: 2007-02-01

Catheter Evaluation for Endocardial Ablation in Patients With Ventricular Tachycardia Start of enrollment: 2007-01-01

REASSURE AV Registry Start of enrollment: 2006-04-01

Catheter Evaluation for Endocardial Ablation in Patients With Typical Atrial Flutter Start of enrollment: 2006-01-01

RethinQ Study – Evaluating Pacing in Heart Failure Patients Start of enrollment: 2005-07-01

Evaluation of the Safety and Effectiveness of the OPTIMIZER System in Subjects With Heart Failure: FIX-HF-5 Start of enrollment: 2005-02-01

WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation Start of enrollment: 2005-02-01

NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Symptomatic Paroxysmal Atrial Fibrillation Start of enrollment: 2004-10-01

Attain StarFix™ Model 4195 Left Ventricular Lead Start of enrollment: 2004-07-01

PREFER (Pacemaker Remote Follow-Up Evaluation and Review) Start of enrollment: 2004-04-01

Safety and Efficacy of the CryoCor™ Cardiac Cryoablation System for the Treatment of Atrial Flutter Start of enrollment: 2004-01-01

MASTER I – Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients Start of enrollment: 2003-10-01

Clinical Study of the EASYTRAK 3 Spiral Fixation Coronary Venous Bipolar Pace/Sense Lead Start of enrollment: 2003-05-01

Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest Start of enrollment: 2002-09-01

Optimal Pharmacological Therapy In Implantable Defibrillator Patients (OPTIC) Start of enrollment: 2001-01-01

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