Tikosyn / Dofetilide

How can I find out which retail pharmacies are enrolled in the program and can stock and dispense TIKOSYN?

Patients and physicians can call 1-877-TIKOSYN and speak to a Customer Service Representative (CSR) to find out if a pharmacy is enrolled in T.I.P.S.â„¢ The CSR can provide this information when given the name, address, or ZIP code for the pharmacy. If a pharmacy is not enrolled in the T.I.P.S.â„¢ program, the pharmacist can call 1-877-TIKOSYN to learn how to enroll and order TIKOSYN. To find out if a pharmacy stocks TIKOSYN, the patient or physician must call the pharmacy directly. The CSR at 1-877-TIKOSYN can provide the name/number of the enrolled pharmacy. For more information visit manufacturer website http://tikosyn.com

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What are contraindications for use of TIKOSYN?

Concomitant administration of TIKOSYN® (dofetilide) is contraindicated with:     * Cimetidine     * Verapamil     * Ketoconazole     * Sulfamethoxazole/trimethoprim     * Prochlorperazine     * Megestrol     * Hydrochlorothiazide/triamterene TIKOSYN is also contraindicated in patients with:     * Congenital or acquired long-QT syndromes     * Severe renal impairment     * Hypersensitivity to TIKOSYN

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How is TIKOSYN dosed?

Therapy with TIKOSYN must be initiated (and, if necessary, re-initiated) in a setting that provides continuous electrocardiographic (ECG) monitoring and in the presence of personnel trained in the management of serious ventricular arrhythmias. Patients should continue to be monitored in this way for a minimum of 3 days. Additionally, patients should not be discharged within 12 hours of electrical or pharmacological conversion to normal sinus rhythm. The dose of TIKOSYN must be individualized according to patient” renal function (calculated creatinine clearance) and QTc. (QT interval should be used if the heart rate is <60 beats per minute. There are no data on use of TIKOSYN when the heart rate is <50 beats per minute.) The usual recommended dose of TIKOSYN is 500 mcg BID.

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What is TIKOSYN indicated for?

TIKOSYN is indicated for the maintenance of, and conversion to, normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter) of greater than 1 week duration in highly symptomatic patients with persistent atrial fibrillation /atrial flutter.

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When should I be seen after my hospitalization?

You should be seen in our office in one month for follow up. Please contact the office (602)234-2800 to schedule your follow up appointment.

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How will I know the medication is working?

The medication effectiveness is determined by a change in your heart’s current rhythm. You may not immediately be aware of any change in your heart’s rhythm. ECG’s and vital signs will be reviewed by your physician and will determine what dose is correct for you.

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Will I be wearing a monitor while in the hospital?

Yes. You will be wearing a portable or “telemetry” monitor throughout your hospitalization. This will allow you to move around freely while your heart’s rhythm is continuously monitored. You will also have a series of electrocardiograms (ECG’s) that will document your heart’s response to this medication.

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Is this medication given intravenously?

No. Tikosyn is given to you orally in capsule form every twelve hours. The specific dosage administered will be determined by your physician.

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Why does Tikosyn require a hospital admission and for how long?

A typical hospitalization is 72 hours.  Tikosyn is a medication that is designed to treat your cardiac arrhythmia.  Close monitoring is required while tikosyn is administered because of its potent effect on the heart’s rhythm. Once proper dosing has been established for you to treat your arrhythmia, you will be discharged from the hospital.  It is very important for you to continue your medication as prescribed.  It is important not to “skipâ€� or miss doses of tikosyn.  It should be taken every 12 hours as prescribed. For additional information on Tikosyn, please visit their Website http://tikosyn.com

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